This chicken and shrimp alfredo is everything you love about comfort food—rich, creamy, and packed with flavor. Tender chicken, juicy shrimp, and silky Alfredo sauce coat every bite of pasta, making this an unforgettable dish. Whether you’re cooking for a weeknight dinner or impressing guests, this recipe comes together fast and tastes like it came straight from a restaurant.

Why You’ll Love Chicken and Shrimp Alfredo

Quick and easy to make in under 40 minutes
Perfectly seasoned with Cajun spices for a flavorful kick
Creamy Alfredo sauce made with real parmesan and cream cheese
Crowd-pleaser for both kids and adults
Easy to customize with your favorite pasta or add-ins

Ingredients for Chicken and Shrimp Alfredo

Main Ingredients

Fettuccine pasta
Chicken breasts
Shrimp
Garlic powder
Cajun seasoning
Olive oil
Butter
Heavy cream
Cream cheese
Garlic
Parmesan cheese
Salt
Black pepper

Optional Garnishes

Chopped fresh parsley
Extra grated parmesan
Crushed red pepper flakes

Equipment

Large skillet
Medium saucepan
Mixing bowls
Measuring cups
Measuring spoons
Colander

Utensils

Wooden spoon
Chef’s knife
Cutting board
Tongs
Whisk

Variations

Swap the fettuccine for penne, linguine, or spaghetti
Make it spicy by adding more Cajun seasoning or a pinch of cayenne
Add sautéed mushrooms or spinach for extra veggies
Use half-and-half instead of heavy cream for a lighter version
Try smoked sausage instead of chicken for a different twist

How to Make Chicken and Shrimp Alfredo

Step 1: Season the Chicken and Shrimp

First, cut the chicken breasts into bite-sized pieces. Place them in a bowl with the peeled and thawed shrimp. Sprinkle garlic powder and half of the Cajun seasoning over the top. Mix everything well so the chicken and shrimp are evenly coated.

Seasoning chicken and shrimp for alfredo

Step 2: Cook the Chicken and Shrimp

Heat olive oil in a large skillet over medium-high heat. Once hot, add the chicken pieces and cook for about 5 minutes until lightly browned. Add the shrimp and cook for another 2–3 minutes, just until pink and cooked through. Remove the chicken and shrimp from the skillet and set them aside.

Step 3: Make the Alfredo Sauce

In the same skillet, reduce the heat to medium and add butter. Once melted, stir in the minced garlic and cook for 30 seconds. Pour in the heavy cream and add cream cheese. Stir until the cream cheese melts and blends in. Sprinkle in the remaining Cajun seasoning and stir. Add the grated parmesan and whisk until the sauce is smooth and creamy.

Second step – cooking the seasoned chicken and shrimp for alfredo

Step 4: Combine Pasta, Chicken, Shrimp, and Sauce

While making the sauce, boil the fettuccine in a separate pot according to package directions. Drain and add the pasta to the Alfredo sauce. Return the cooked chicken and shrimp to the skillet. Toss everything together so the sauce coats each bite evenly. Taste and add salt and pepper if needed.

Finished chicken and shrimp alfredo pasta

Tips and Tricks

Use freshly grated parmesan for the smoothest, richest sauce
Don’t overcook the shrimp—they cook quickly and can become rubbery
If the sauce gets too thick, add a splash of pasta water to loosen it
Want a restaurant-style finish? Garnish with a sprinkle of parsley and parmesan

How to Serve Chicken and Shrimp Alfredo

This chicken and shrimp alfredo pairs well with garlic bread or a crisp side salad. Serve it hot straight from the skillet, and let each person top their dish with extra parmesan or a pinch of red pepper flakes.

Make Ahead and Storage

To make ahead, prep the chicken and shrimp a day in advance and store them in the fridge. The sauce can also be made early and reheated gently. Store leftovers in an airtight container in the fridge for up to 3 days. Reheat slowly on the stove or in the microwave with a splash of cream or milk to loosen the sauce.

FAQs

Can I use frozen shrimp?
Yes, just make sure to thaw and pat them dry before cooking.

Can I make this without Cajun seasoning?
Absolutely. Use Italian seasoning or a mix of paprika, garlic, and onion powder instead.

Can I make this gluten-free?
Yes, use your favorite gluten-free pasta and double-check that your seasonings and cheese are gluten-free.

How do I know when the shrimp is done?
Shrimp is fully cooked when it turns pink and curls into a C shape.

Conclusion

In the end, this chicken and shrimp alfredo is the kind of meal that brings everyone to the table with smiles. It’s rich, flavorful, and surprisingly simple to make. Give it a try tonight, and you’ll see why it’s a family favorite.

If you loved this creamy Chicken and Shrimp Alfredo, you’ll definitely want to try our rich and elegant Lobster Linguine for another seafood-inspired favorite. On cooler days, warm up with a comforting bowl of Chicken and Potato Soup that’s both hearty and easy to make. Or, if you’re craving something fresh and zesty, this Mexican Chicken Salad is packed with bold flavors and perfect for a lighter meal.

Alfredo sauce has a rich history that dates back to early 20th-century Italy, originally made with just butter and parmesan cheese. You can learn more about its origins by visiting the Fettuccine Alfredo page on Wikipedia. This dish also highlights the versatility of shrimp as a protein, which pairs beautifully with creamy sauces and pasta. Additionally, the blend of spices used in this recipe, especially Cajun seasoning, is rooted in the flavorful traditions of Cajun cuisine, known for its bold and hearty cooking style.